Klotho peptide
WebOct 22, 2024 · The klotho family and structure. Klotho family members include α-, β-, and γ-klotho genes based on their predicted primary sequences [18, 19]. β- and γ-klotho were discovered based on their homology with α-klotho, and they all share a single-pass transmembrane protein [20, 21]. β-Klotho is predominantly expressed in the liver but is … WebDescription Rabbit polyclonal to Klotho Host species Rabbit Tested applications Suitable for: IHC-P more details Species reactivity Reacts with: Mouse, Rat Immunogen Synthetic peptide within Human Klotho aa 400-500 conjugated to keyhole limpet haemocyanin. The exact immunogen sequence used to generate this antibody is proprietary information.
Klotho peptide
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Webklotho protein can be cleaved and released as a soluble protein, which can be detected in cerebrospinal fluid and blood. Soluble klotho protein can act as an independent hormonal factor that regulates the activity of various growth factor signaling pathways (insulin/IGF-1 and Wnt) and various ion channels. WebKlotho protein is a β-glucuronidase capable of hydrolyzing steroid β-glucuronides. Two molecules are produced by the Klotho gene, a membrane bound form and a circulating …
WebOther studies have suggested that Klotho overexpression may have a protective effect on nerves and reduce nerve sensitivity. For example, a study published in the Journal of Neuroinflammation in 2024 showed that Klotho overexpression reduced neuropathic pain in rats by reducing inflammation and oxidative stress in the spinal cord. While these ... WebThe two forms of Klotho protein, membrane Klotho and secreted Klotho, exert distinct functions. Membrane Klotho forms a complex with fibroblast growth factor (FGF) …
WebThe klotho gene was identified as an "aging-suppressor" gene in mice that accelerates aging when disrupted and extends life span when overexpressed. It encodes a single-pass transmembrane protein and is expressed primarily in renal tubules. The extracellular domain of Klotho protein is secreted into blood and urine by ectodomain shedding. WebMar 9, 2024 · The aging-related protein α-Klotho (hereinafter called Klotho) is a transmembrane protein, functioning as a co-receptor of fibroblast growth factor 23 (FGF23) with fibroblast growth factor receptors 1, 2, and 4 (FGFR). 1 - 4 The FGFR/Klotho/FGF23 complex regulates phosphate and calcium homeostasis in the kidney.
WebFeb 20, 2024 · The Klotho gene and protein were discovered in 1997 by a scientist named Makoto Kuro-o. The name Klotho refers to the Greek mythological story of the three …
WebKlotho, an antiaging protein closely related to arteriosclerosis, is mainly expressed in the kidney, 3 and its expression decreases with age. 4 Klotho proteins are divided into membrane-bound, soluble and secreted forms, and circulating Klotho includes soluble and secreted forms. 5 Studies have shown that the expression of circulating blood ... tiffany eunick graveWebThe Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. Tissue specificity. Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. tiffany eunick obituaryWebKLOTHO peptide is used for blocking the activity of KLOTHO antibody.Proteins are used in routine laboratory procedures such as binding enzymes or coupling peptides to carrier … the mayfair hotel mayfair londonWebJun 11, 2024 · Klotho is a natural protein enzyme that exists within the body and brain. This protein is created by the KL gene and is produced in the kidneys. It appears to have a large role in the regulation of phosphate, but this is only a … tiffany evans and jawan harrisWebKlotho Proteins We offer Klotho Peptides and Klotho Proteins for use in common research applications: Blocking/Neutralizing. Each Klotho Peptide and Klotho Protein is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. the mayfair hotel parisWebProduct Specific Information This peptide corresponds to 16 amino acid peptide near the center of human KLOTHO. PEP-1192 can be used as a blocking peptide with polyclonal … tiffany evans againWebFeb 20, 2024 · The Klotho gene and protein were discovered in 1997 by a scientist named Makoto Kuro-o. The name Klotho refers to the Greek mythological story of the three Fates. Klotho spun the thread of human life. tiffany evans i\u0027ll be there